Make your own all natural On Guard hand sanitizer spray that is highly effective

Make your own hand sanitizer spray with OnGuard essential oil from doTERRA

Learn how to make DIY On Guard Hand Sanitizer Spray with this recipe that I have been using for years.     

doTERRA On Guard essential oil is the perfect choice for keeping hands and surfaces clean due to it’s immune system boosting properties.

doTERRA OnGuard Hand Sanitizer spray kills 99.99% of germs and bacteria with plant based alcohol and OnGuard essential oil blend

You can always BUY premade On Guard Hand Sanitizer – you can do so in my shop HERE.

However, if you’re looking to save a bit of money, it’s super simple to make your own. You can even refill those bottles the premade sanitizer comes in.

 I quit purchasing traditional hand sanitizers years ago since those can kill the good bacteria that act as a first line of defense for our bodies.   We need all the help we can get. 

How to make hand sanitizer with doTERRA OnGuard essential oil

How and When to use On Guard Hand Sanitizer Spray

I always keep several of these DIY On Guard Hand Sanitizer Sprays handy all the time.  Here’s several suggestions for ways to use these:

  • I have 2 or 3 in the console of my car to spray hands when getting back in the car,
  • several in my purse to use on hands, menus, shopping carts, etc.
  • One in each bathroom to spray toilet handles and seats 
  • In the kitchen to spray off grocery packaging 
  • and in my kid’s lunchboxes. ( I like to think they use them, but I’m pretty sure my 13 year old is way too cool to do that.)

We use the On Guard Sanitizer Spray on EVERYTHING.  Anything that is a high touch surface.  When you are out and about, think about how many hands have touched a surface before you. 

These surfaces can include:

  • Tables at restaurants (have you ever thought about how they use the same cloth to wipe multiple tables?)
  • Door handles
  • menus
  • shopping cart handles
  • my purse handles
  • my phone
  • my hands and my kid’s hands after touching literally ANYTHING
  • in my kid’s lunchboxes so they can spray their hands before eating. (I know at least one of them uses it)
  • and any other “high touch” surface like doorknobs, toilets, faucets.

Please note that I use affiliate links in this article.  If you make a purchase, I may earn a small commission which goes towards the cost of running this website.  Your price is not affected.

It is super easy to make your own Hand Sanitizer with doTERRA On Guard Essential Oil.  You can save those spray bottles from the premade sanitizer, and refill them  If you don’t have any to reuse, you can purchase some like these on Amazon.  

Supplies to Make Your DIY On Guard Hand Sanitizer Spray

1. Spray Bottles for your DIY On Guard Hand Sanitizer Spray

Grab this pack of 8 spray bottles from Amazon that even comes with funnels.

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Since you’ll have 8 spray bottles, mix up several of these Hand Santizers and leave one in each of these locations where you’re likely to want one:

  • each bathroom
  • in the kitchen 
  • one to leave in the car 
  • in your purse 
  • in your kid’s lunchboxes

You can also use these for room sprays, sleep sprays, and body sprays.

2. Isopropyl Alcohol in your On Guard Hand Sanitizer

I’ve been making this exact recipe for years.  I don’t typically add the alcohol, but desperate times call for desperate measures when we’re in a global pandemic.  

Please note that doTERRA uses a plant based ethyl alcohol in their On Guard Hand Spray recipe – not isopropyl alcohol.  

Medical Grade Isopropyl Alcohol Safe for Skin

I found this Medical Grade Isopropyl Alcohol that is safe for hands and skin.  Check to see if it is currently in stock

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If you can’t find Isopropyl Alcohol, I’ve heard you can use Everclear because it has a high enough alcohol content, but I have no scientific backing for that.  Use at your own discretion.  Many people have been resorting to vodka, but it does not have a high enough alcohol content to effectively kill viruses.

3. Carrier Oil for your DIY On Guard Hand Sanitizer Spray

Some people like to use Carrier Oil in this recipe.  I really feel like it’s a personal preference.  Personally – I use plain old water when I make these On Guard Sanitizers.  

I’m sure you’ve heard the saying “oil and water don’t mix”, which is why many people prefer to use carrier oil in this recipe.  The essential oils will bind to the carrier oil.  But – I’ve found water works just fine as long as I give the bottle a little shake before spraying it.

I recommend making one each way and deciding for yourself which you prefer.  

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If you need to pick up some carrier oil – I recommend this Jojoba Oil from Amazon.  Fractionated coconut oil will also work if that’s your preferred carrier oil.  

You’ll be able to use the jojoba oil in many other essential oil DIY’s such as my DIY facial serum recipe and DIY bodywash.

I like this one because it’s hexane free, cold pressed, and has a handy pump which makes it really easy to get into my small spray bottle.  It’s a big bottle and lasts a long time!

Directions to Make your On Guard Hand Sanitizer Spray

If you found this recipe for On Guard Hand Sanitizer Spray helpful, please give it a quick star rating in the recipe below, or comment below.

how to make your own OnGuard hand Sanitizer Spray with doTERRA onGuard essential oil

DIY OnGuard Hand Sanitizer Spray

Author: Dawn Goehring
DIY OnGuard Hand Sanitizer Spray with or without alchohol. Use this homemade spray with doTERRA OnGuard Essential Oil on hands, high touch surfaces, and around the house to kill germs. The spray is 99.99% effective against germs and bacteria and is safe for kids and children.
5 from 6 votes
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  • mini funnels



  • Add the OnGuard drops to your spray bottle
  • Add the alcohol to your spray bottle. Skip this step if you're not using alcohol.
  • Top off the spray bottle with your carrier oil or water.
  • Shake gently to combine. 


Make sure to shake gently before each use, as the ingredients will separate.

How to make your own doTERRA OnGuard Hand Sanitizer Spray using onguard essential oil from doTERRA and rubbing alcohol

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About The Author

Dawn Goehring Desert Naturals Essential Oils

Dawn Goehring

Owner / Founder of Desert Naturals

Dawn Goehring is the founder of Desert Naturals where she writes educational articles on essential oils, DIY's on natural beauty products, homemade cleaners, and provides related essential oil accessories like Planners, Journals, Trackers, tshirts, and custom made essential oil storage.

Dawn discovered essential oils about 10 years ago to support her then 4 year old son who was struggling to manage a respiratory condition. She then learned how to use essential oils for everyday natural remedies for her family, and has helped hundreds of women incorporate essential oils in their lives to live a healthier, more holistic lifestyle using natural products and essential oils.

Dawn has earned an aromatherapist degree and has earned a doTERRA essential oil specialist certification which is a fancy way of saying she has learned a lot about the chemistry of essential oils and how they work in the body.

8 thoughts on “DIY On Guard Hand Sanitizer Spray Recipe”

  1. Hi Cheryl,

    Thanks for pointing out the castile soap and glycerin. I’m not sure where they came from but neither is not an ingredient in this recipe. I’ve updated the recipe so it’s no longer there.

  2. Thank you for your instructions for making this hand spray. I usually buy the pre-made stuff but its unavailable now so this post is very helpful!
    I noticed that you’re under the impression that restaurants use the same rag all night. This is simply not true. Rags are changed frequently throughout the day and night. While the same rag may be used for more than one table it isn’t used for too long. Just thought I’d ease your mind and direct you away from touting misinformation on your site.

    1. Good to know they change them out, Jess. I’m a big time germaphobe so I tend to get a little nuts on stuff like this. My family is constantly rolling their eyes every time I pull my spray out and start spraying like a fanatic. 😉

  3. I’ve been doing this all during the COVID19 virus, except I’ve been using aloe Vera gel instead of oil. Love making our own.

  4. Just Finished making the hand sanitizer recipe! Poured it in an empty doTERRA Sanitizing Mist bottle.
    Thank you! I love this recipe!

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